Most commonly this puja is performed to assist in the recovery of illness, or an operation. It is also done to achieve higher rebirth for the deceased.

The Medicine Buddha Puja can be performed extensivly, with the requests to Medicine Buddhas donseven times to each of the Buddhas. Additonal prayers are said for the dedication of the merit.

The same puja can be performed in a shorter version as well.

By creating extensive merit through the performance of the puja, Medicine Buddha puja is also very helpful to bring success in all activities, for example work related.